Semax — Research Peptide Bulk Supply
Also known as: ACTH(4-7)-PGP, Met-Glu-His-Phe-Pro-Gly-Pro, Heptapeptide Semax, MEHFPGP
Semax (MEHFPGP) — 7-residue ACTH(4-7)-PGP nootropic research peptide. Wholesale bulk supply, COA/HPLC-MS, bulk distributor.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- Molecular weight: 813.9 g/mol
- Available in research vial sizes (30 mg) and bulk aliquot programs
- N-acetyl amidate form (enhanced stability and bioavailability) available
- COA with HPLC and mass spectrometry data per lot
- Cold-chain shipping and storage documentation
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP) |
|---|---|
| Residue count | 7 |
| Molecular formula | C37H51N9O10S |
| Molecular weight | 813.9 g/mol |
| PubChem CID | 9811102 |
Research Mechanism Summary
Semax is a synthetic heptapeptide (MEHFPGP) derived from the N-terminal fragment (4-10) of adrenocorticotropic hormone (ACTH) but completely devoid of classical hormonal ACTH activity; intranasal application in rodent models produces 1.4–3-fold increases in hippocampal BDNF protein and trkB receptor mRNA, suggesting a BDNF/trkB-mediated mechanism for observed cognitive-enhancing effects (https://pubmed.ncbi.nlm.nih.gov/16996037/). Ischemia model research demonstrates that Semax normalizes mRNA expression patterns disrupted by transient middle cerebral artery occlusion, specifically suppressing inflammatory gene expression while activating neurotransmitter-system genes (https://pmc.ncbi.nlm.nih.gov/articles/PMC7350263/). A 2026 study in Acta Naturae reports that both Semax and a derivative improved cognitive function and reduced amyloid load in an Alzheimer's disease mouse model (https://pmc.ncbi.nlm.nih.gov/articles/PMC12755871/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Semax is supplied as a research-grade lyophilized peptide catalog item under the Neuropeptide & Cognitive Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Semax in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.