MOTS-c — Research Peptide Bulk Supply
Also known as: Mitochondrial Open Reading Frame of the 12S rRNA Type-C, Mitochondrial-Derived Peptide MOTS-c
MOTS-c — 19-residue mitochondria-derived peptide. AMPK pathway research. Wholesale bulk supply, COA/HPLC-MS distributor.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- Molecular weight: 2174.6 g/mol (19 residues)
- Available in research vial sizes (5 mg, 10 mg) and bulk aliquot programs
- COA with HPLC and mass spectrometry data per lot
- Cold-chain shipping and storage documentation
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Phe-Tyr-Pro-Arg-Lys-Leu-Ala-Lys-Glu-Ile-Arg (MRWQEMGYFYPRKLAKELR — note: verify with primary source) |
|---|---|
| Residue count | 19 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| PubChem CID | 146675088 |
Research Mechanism Summary
MOTS-c is a 19-residue peptide encoded by the 12S ribosomal RNA gene of the mitochondrial genome; it serves as an endogenous regulator of cellular energy homeostasis by activating AMPK and the downstream PGC-1α pathway to enhance mitochondrial bioenergetic efficiency and reduce reactive oxygen species (ROS) emission in skeletal muscle models (https://pubmed.ncbi.nlm.nih.gov/41520850/). Research demonstrates MOTS-c activates the AMPK-HIF-1α-PFKFB3 glycolytic axis to preserve cellular energy homeostasis and suppress ferroptosis under ischemic stress (https://pubmed.ncbi.nlm.nih.gov/40035775/), and suppresses RANKL-induced osteoclast differentiation via AMPK-dependent inhibition in a bone loss model (https://pubmed.ncbi.nlm.nih.gov/27237975/). Its mitochondrial genomic origin makes it a unique endocrine signaling molecule that translocates to the nucleus under stress conditions.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
MOTS-c is supplied as a research-grade lyophilized peptide catalog item under the Mitochondrial & Longevity Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies MOTS-c in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.