PT-141 (Bremelanotide) — Research Peptide Bulk Supply
Also known as: Bremelanotide, PT141, Vyleesi
PT-141 (Bremelanotide, Vyleesi) — cyclic MC4R research peptide. Wholesale bulk supply, COA/HPLC-MS, private-label distributor.
Bremelanotide (Vyleesi) is FDA-approved for HSDD in premenopausal women. The page below frames melanocortin receptor research context only.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- Molecular weight: ~1025 g/mol (cyclic heptapeptide)
- Available in research vial sizes (3 mg, 10 mg) and bulk aliquot programs
- COA with HPLC and mass spectrometry data per lot
- Cold-chain shipping and storage documentation
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH (cyclic lactam, C-terminal acid vs. MT-II amide) |
|---|---|
| Residue count | 7 |
| Molecular formula | C50H68N14O10 |
| Molecular weight | ~1025 g/mol |
| PubChem CID | 9941379 |
| Note | FDA-approved as Vyleesi (HSDD treatment) |
Research Mechanism Summary
Bremelanotide (PT-141) is a cyclic 7-residue peptide derived from Melanotan II with a lactam ring and a free carboxylic acid C-terminus (replacing the MT-II amide); it acts as a non-selective melanocortin receptor agonist with primary activity at MC4R and MC3R in the CNS, where it modulates the neural circuits governing sexual desire and arousal independent of vascular mechanisms (https://pubchem.ncbi.nlm.nih.gov/compound/9941379). It is FDA-approved as Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women, and its MC4R mechanism was characterized in receptor subtype studies demonstrating erectile function modulation via spinal cord circuitry and somatosensory afferent pathways (https://pmc.ncbi.nlm.nih.gov/articles/PMC123265/). Unlike Melanotan II, the free carboxylic acid terminus reduces melanogenic activity relative to amide analogues.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
PT-141 (Bremelanotide) is supplied as a research-grade lyophilized peptide catalog item under the Melanocortin Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies PT-141 (Bremelanotide) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.