Gonadorelin — Research Peptide Bulk Supply
Also known as: GnRH, LHRH, Gonadotropin-Releasing Hormone, Luteinizing Hormone-Releasing Hormone
Gonadorelin (GnRH/LHRH) — native 10-residue gonadotropin-releasing hormone. Wholesale bulk, COA/HPLC-MS, private-label supply.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- Molecular weight: ~1182.3 g/mol (pyroglutamyl decapeptide, C-terminal amide)
- Available in research vial sizes (10 mg) and bulk aliquot programs
- COA with HPLC and mass spectrometry data per lot
- Cold-chain shipping and storage documentation
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
|---|---|
| Residue count | 10 |
| Molecular formula | C55H75N17O13 |
| Molecular weight | ~1182.3 g/mol |
| PubChem CID | 638793 |
| Note | N-terminal pyroglutamate (pGlu) is a cyclized glutamic acid residue |
Research Mechanism Summary
Gonadorelin (GnRH) is the native 10-residue hypothalamic decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) that stimulates luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from anterior pituitary gonadotrophs by binding the GnRH receptor (GnRHR), a GPCR whose activation triggers PKC, MAPK/ERK, and Ca2+ signaling cascades (https://pmc.ncbi.nlm.nih.gov/articles/PMC3947649/). Differential GnRH pulse frequencies encode distinct gonadotropin outputs: faster frequencies (every 30–90 min) favor LH-β transcription via EGR1, while slower frequencies favor FSH-β transcription, providing the basis for the HPG axis's reproductive cycle control (https://pmc.ncbi.nlm.nih.gov/articles/PMC3947649/). Continuous GnRH desensitizes the pituitary, while pulsatile delivery sustains LH and FSH secretion (https://pmc.ncbi.nlm.nih.gov/articles/PMC10201305/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Gonadorelin is supplied as a research-grade lyophilized peptide catalog item under the Reproductive & Neuroendocrine Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Gonadorelin in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.