PE-22-28 — Research Peptide Bulk Supply
Also known as: Spadin analogue PE-22-28, TREK-1 antagonist peptide
PE-22-28 is a synthetic spadin analogue studied for TREK-1 channel inhibition and hippocampal neurogenesis. Lyophilized research peptide, >99% purity.
PE 22-28 is a truncated spadin analogue listed for TREK-1 ion channel and neuropharmacology research framing only — no treatment, antidepressant, or clinical claims are made.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 5 mg, 8 mg, 10 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in sterile water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | 7-residue truncated spadin analogue; exact sequence per original Borsotto et al. publications |
|---|---|
| Residue count | 7 |
| Molecular formula | TBD |
| Molecular weight | TBD |
Research Mechanism Summary
PE-22-28 is a synthetic truncated analogue of spadin, a peptide derived from the pro-region of sortilin. It functions as a potent antagonist of the TREK-1 (TWIK-related K+ channel 1) potassium channel, an important regulator of neuronal excitability linked to depressive phenotypes in murine genetic studies. By blocking TREK-1, PE-22-28 modulates potassium ion flux and downstream neurotransmitter dynamics, triggering hippocampal neurogenesis within days in rodent depression models—roughly doubling BrdU-positive (newly dividing) cell counts and elevating PSD-95, synapsin, and BDNF mRNA (https://www.corepeptides.com/pe-22-28-peptide-depression-and-neurogenesis-research/). Complementary research characterizes PE-22-28 as a TrkB receptor agonist that mimics BDNF signaling through the PI3K/Akt and MAPK/ERK pathways, supporting neural survival and synaptic plasticity (https://revolutionhealth.org/blogs/news/peptide-therapy-pe-22-28). Enhanced in vitro stability relative to native spadin makes it a practical neurological research probe.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
PE-22-28 is supplied as a research-grade lyophilized peptide catalog item under the Neuropeptide & Cognitive Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies PE-22-28 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.