Dihexa — Research Peptide Bulk Supply
Also known as: PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, BGC70883
Dihexa (PNB-0408) is an orally active angiotensin IV-derived oligopeptide that potentiates HGF/c-Met signaling and synaptogenesis in preclinical models.
Dihexa (PNB-0408) is a research-only HGF/c-Met pathway tool. All cited data is preclinical; no human clinical trials have been published. No cognitive enhancement, treatment, or therapeutic claims are made.
Bulk Catalog Specifications
- Lyophilized powder
- Purity ≥98% (HPLC)
- MW: 504.7 g/mol
- Orally bioavailable small oligopeptide (3 amino acid backbone with N-hexanoyl and aminohexanoyl modifications)
- Storage: −20°C, desiccated
- COA: HPLC, MS, optical rotation
Scientific Identifiers
| Residue count | 3-equivalent (modified dipeptide backbone with non-amino acid extensions) |
|---|---|
| Molecular formula | C27H44N4O5 |
| Molecular weight | 504.7 g/mol |
| PubChem CID | 125355097 |
Research Mechanism Summary
Dihexa (PNB-0408) is an orally active oligopeptide derived from angiotensin IV that crosses the blood-brain barrier and binds hepatocyte growth factor (HGF) with extraordinarily high affinity (Kd ~65 pM), potentiating HGF signaling at its receptor c-Met on brain cells. Activation of the HGF/c-Met pathway promotes dendritic spine formation and synaptogenesis in rodent hippocampal models; in aged animals with cognitive impairment and scopolamine-challenged models, Dihexa administration has been associated with restored memory performance and increased synapse density. The compound was developed at Washington State University and is being pursued commercially through M3 Biotechnology under the fosgonimeton clinical program, though Dihexa itself remains in preclinical stages with no published human trial data.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Dihexa is supplied as a research-grade lyophilized peptide catalog item under the Neuropeptide & Cognitive Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Dihexa in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.