P21 (P021) — Research Peptide Bulk Supply
Also known as: P021, Peptide 6, CNTF Mimetic Tetrapeptide, DGGL Peptide
P21 (P021) is a CNTF-mimetic tetrapeptide studied for hippocampal neurogenesis, BDNF/TrkB signaling, and synaptic plasticity in Alzheimer's models.
Bulk Catalog Specifications
- Lyophilized powder
- Purity ≥95% (HPLC)
- Residue count: 4 (tetrapeptide with adamantane modification)
- MW: approx. 500-700 Da (adamantyl-DGGL, MW varies by salt form)
- Storage: −20°C, light-protected
- COA: HPLC, MS sequence confirmation
Scientific Identifiers
| Sequence | Adamantane-DGGL (Asp-Gly-Gly-Leu with N-terminal adamantane) |
|---|---|
| Residue count | 4 |
| Molecular formula | Not confirmed in PubChem under 'P21' — synonymous with P021/Peptide 6 in Iqbal lab publications |
| Molecular weight | Approx. 500-650 Da (adamantane-modified tetrapeptide) |
| PubChem CID | Not confirmed |
Research Mechanism Summary
P21 (also designated P021 or Peptide 6) is a synthetic tetrapeptide mimetic of ciliary neurotrophic factor (CNTF), derived through epitope mapping of Cerebrolysin with adamantane added for BBB permeability. Its core pharmacophore (DGGL) activates CNTF receptor complexes while avoiding the severe weight loss and immunogenicity of full-length CNTF administration. P21 treatment in 3xTg-AD mouse models significantly increased hippocampal neurogenesis (Ki-67 and doublecortin markers), normalized BDNF/TrkB/pCREB signaling, and reversed dendritic and synaptic deficits without reduction of amyloid plaque burden, indicating synaptic compensation rather than disease-modification as its primary mechanism.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
P21 (P021) is supplied as a research-grade lyophilized peptide catalog item under the Neuropeptide & Cognitive Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies P21 (P021) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.