Humanin — Research Peptide Bulk Supply
Also known as: HN, Humanin-G, HNG, Mitochondrial-Derived Peptide (MDP), MTRNR2
Humanin is a 24-aa mitochondrial-derived peptide studied for neuroprotection, Bax inhibition, cytoprotection, and aging biology. Research-grade bulk specs.
Humanin's anti-apoptotic mechanism is well documented in mitochondrial-derived peptide research. Note: humanin's role in cancer biology is an active area of literature complexity. Listed strictly as a mechanistic research tool.
Bulk Catalog Specifications
- Lyophilized powder (synthetic)
- Purity ≥98% (HPLC)
- Residue count: 24 amino acids
- MW: ~2687 Da
- Storage: −20°C lyophilized; −80°C in solution
- COA: HPLC, MS sequence confirmation, endotoxin testing
Scientific Identifiers
| Sequence | MAPRGFSCLLLLTSEIDLPVKRRA (human, cytoplasmic code) — 24 aa |
|---|---|
| Residue count | 24 |
| Molecular formula | C119H204N34O32S2 |
| Molecular weight | 2687.2 g/mol |
| PubChem CID | 16131438 |
Research Mechanism Summary
Humanin is a 24-amino acid mitochondrial-derived peptide (MDP) encoded within the 16S rRNA gene of the mitochondrial genome and first identified as a neuroprotective factor in Alzheimer's disease models in 2001. It acts through two receptor systems: the FPRL-1 (formylpeptide receptor-like 1) G protein-coupled receptor and the trimeric CNTFR/WSX-1/gp130 complex, activating JAK2/STAT3, ERK1/2, and PI3K/AKT survival pathways. A second mechanism involves direct intracellular binding to the pro-apoptotic protein Bax, preventing its mitochondrial translocation and blocking cytochrome C release — providing cytoprotection against oxidative stress, ischemia-reperfusion injury, and amyloid-beta toxicity across neural, cardiac, reproductive, and metabolic cell types.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Humanin is supplied as a research-grade lyophilized peptide catalog item under the Mitochondrial-Derived Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Citations & Sources
- https://pubchem.ncbi.nlm.nih.gov/compound/16131438
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3641182/
- https://pubmed.ncbi.nlm.nih.gov/33130077/
- https://pubmed.ncbi.nlm.nih.gov/33764899/
- https://www.aging-us.com/article/103534/text
- https://rethinkpeptides.com/articles/humanin-the-cytoprotective-peptide-from-your-mitochondria
Wholesale & Documentation
PeptideDistro.com supplies Humanin in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.