Myostatin Propeptide — Research Peptide Bulk Supply
Also known as: GDF-8 Propeptide, Myostatin LAP, Myostatin Latency-Associated Propeptide
Myostatin propeptide is the N-terminal latency domain of GDF-8 studied for myostatin inhibition, muscle hypertrophy, and muscular dystrophy models.
Myostatin propeptide is the endogenous inhibitor of myostatin (GDF-8). Listed for myostatin-pathway research only; no performance or muscle-growth claims are made.
Bulk Catalog Specifications
- Recombinant protein (E. coli or mammalian cell expression)
- Lyophilized
- MW: varies by construct and glycosylation state (~36-42 kDa recombinant)
- Wild-type or D76A stabilized form — specify at order
- Purity ≥95% (SDS-PAGE)
- Storage: −80°C long-term
- COA: SDS-PAGE, myostatin binding assay data, MS confirmation
Scientific Identifiers
| Sequence | N-terminal domain of human GDF-8 (MSTN gene); D76A mutant commonly used in research |
|---|---|
| Residue count | ~243 (human propeptide domain, positions 1-243 of myostatin precursor) |
| Molecular formula | Not reliably calculated (large glycoprotein, varies by construct) |
| Molecular weight | ~36,000–42,000 (36–42 kDa, recombinant; varies by glycosylation) |
| PubChem CID | Not confirmed |
Research Mechanism Summary
Myostatin propeptide is the N-terminal latency-associated peptide domain of the myostatin (GDF-8) precursor protein, cleaved by furin-like proteases during post-translational processing. After cleavage, the propeptide associates non-covalently with the mature C-terminal myostatin dimer, maintaining it in a biologically latent state until further activation by BMP-1/tolloid metalloproteinases at aspartate-76. A stabilized D76A mutant form — where the BMP-1/TLD cleavage site is blocked by replacing aspartate with alanine — has been demonstrated in vitro and in vivo to be a more potent myostatin inhibitor than wild-type propeptide, and has been evaluated in mdx mouse models of Duchenne muscular dystrophy, limb-girdle muscular dystrophy 1C, and LGMD2A, showing increased muscle mass, reduced immune cell infiltration, and improved strength.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Myostatin Propeptide is supplied as a research-grade lyophilized peptide catalog item under the Muscle Growth Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Myostatin Propeptide in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.