IGF-1 DES — Research Peptide Bulk Supply
Also known as: DES(1-3)IGF-1, Des IGF-1, Truncated IGF-1, IGF-I Des(1-3)
IGF-1 DES is a truncated 67-aa IGF-1 isoform with reduced IGFBP binding, studied for IGF1R signaling, muscle biology, and PI3K/AKT pathway research.
Bulk Catalog Specifications
- Recombinant E. coli expressed or synthetic
- Lyophilized, non-glycosylated
- Residue count: 67 amino acids (residues 4-70 of human IGF-1)
- MW: ~7.4 kDa (7365-7372 Da)
- Purity ≥97% (SDS-PAGE)
- Storage: −80°C long-term; −20°C short-term
- COA: SDS-PAGE, MS mass confirmation, bioactivity lot data
Scientific Identifiers
| Sequence | Human IGF-1 residues 4-70 (lacks N-terminal GPE tripeptide) |
|---|---|
| Residue count | 67 |
| Molecular formula | C319H495N91O96S7 |
| Molecular weight | 7365.4 g/mol |
| PubChem CID | 135331146 (associated structure) |
Research Mechanism Summary
IGF-1 DES, or DES(1-3)IGF-1, is a truncated 67-amino-acid isoform of insulin-like growth factor-1 (IGF-1) isolated from bovine colostrum and subsequently synthesized recombinantly, characterized by deletion of the N-terminal Gly-Pro-Glu tripeptide (residues 1-3 of standard IGF-1). This truncation substantially reduces IGFBP binding affinity while preserving high-affinity engagement with the IGF-1 receptor (IGF1R), resulting in greater free peptide availability and potentially enhanced receptor signaling per unit of administered peptide in research models. Downstream signaling through IGF1R activates the PI3K/AKT/mTOR pathway central to muscle protein synthesis and cellular proliferation research, and ERK1/2 MAPK cascades relevant to cell survival and differentiation studies.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
IGF-1 DES is supplied as a research-grade lyophilized peptide catalog item under the Muscle Growth Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies IGF-1 DES in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.