IGF-1 LR3 — Research Peptide Bulk Supply
Also known as: Long R3 IGF-1, Long Arg3 IGF-1, Insulin-like Growth Factor-1 Long Arg3
IGF-1 LR3 (Long R3 IGF-1) — 83-residue extended-half-life IGF-1 analogue. Wholesale bulk, COA documentation, distributor.
Bulk Catalog Specifications
- Recombinant protein, ≥95% purity by SDS-PAGE and HPLC
- Molecular weight: ~9117.6 g/mol (83 residues, C400H625N111O115S9)
- Available in research quantities and bulk programs
- COA with SDS-PAGE, HPLC, and bioactivity data per lot
- Cold-chain shipping and storage documentation (typically −80 °C)
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | 83-residue: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFSR PASSRGLGSL SGRSDVYQCP PTSEGGLQPL EGNKSVTSLK LTQLDNFSSL FYPEMFGSPG TS (see Wikipedia for full sequence) |
|---|---|
| Residue count | 83 |
| Molecular formula | C400H625N111O115S9 |
| Molecular weight | 9117.6 g/mol |
| PubChem CID | Not a discrete small-molecule PubChem entry (recombinant protein) |
Research Mechanism Summary
IGF-1 LR3 is a recombinant 83-residue analogue of IGF-1 containing an N-terminal 13-residue extension (Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Ser-Leu-Phe-Val-Asn) and an Arg3 substitution that dramatically reduces its affinity for IGF-binding proteins (IGFBPs), resulting in a substantially extended plasma half-life (~20–30 hours vs. ~12–15 minutes for native IGF-1) (https://en.wikipedia.org/wiki/IGF-1_LR3). It binds the IGF-1 receptor (IGF-1R) — a receptor tyrosine kinase — to activate IRS protein recruitment and downstream PI3K/Akt/mTOR and MAPK/ERK pathways governing satellite cell proliferation, protein synthesis, and muscle hypertrophy (https://pubmed.ncbi.nlm.nih.gov/17947802/). Research in human satellite cell models shows IGF-1 colocalizes with and activates satellite cells following acute exercise, supporting its use as a muscle repair research tool (https://pubmed.ncbi.nlm.nih.gov/24669996/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
IGF-1 LR3 is supplied as a research-grade lyophilized peptide catalog item under the Muscle Growth Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies IGF-1 LR3 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.