SS-31 (Elamipretide) — Research Peptide Bulk Supply

• Lyophilized powder, ≥98% purity by HPLC-MS
• Molecular weight: 639.8 g/mol (tetrapeptide, D-amino acid containing)
• Available in research vial sizes (25 mg) and bulk aliquot programs
• COA with HPLC and mass spectrometry data per lot
• Cold-chain shipping and storage documentation
• Private-label and white-label bulk inquiry available

SS-31 (elamipretide) is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) from the Szeto-Schiller peptide family designed to target the inner mitochondrial membrane via electrostatic interactions with cardiolipin; it binds cardiolipin in the inner mitochondrial membrane, inhibiting cytochrome C peroxidase activity, promoting electron transfer, and reducing electron leakage and ROS generation (https://pmc.ncbi.nlm.nih.gov/articles/PMC9192202/). Biophysical studies show SS-31 modulates membrane surface electrostatics in a saturable manner — altering lipid packing and divalent cation (Ca2+) distribution at the membrane interface — providing a mechanistic basis for its mitoprotective properties (https://pubmed.ncbi.nlm.nih.gov/32273339/). Preclinical data demonstrate restored mitochondrial morphology and ATP synthesis efficiency in tafazzin-deficient cardiac models, and the compound has progressed to clinical cardiovascular research trials (https://pmc.ncbi.nlm.nih.gov/articles/PMC11176169/).

For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.

• https://pubchem.ncbi.nlm.nih.gov/compound/11764719
• https://pmc.ncbi.nlm.nih.gov/articles/PMC9192202/
• https://pubmed.ncbi.nlm.nih.gov/32273339/
• https://pmc.ncbi.nlm.nih.gov/articles/PMC11176169/