TB-500 — Research Peptide Bulk Supply
Also known as: Thymosin Beta-4 Fragment (17-23), Tβ4 Active Fragment, Ac-LKKTETQ, TB500
TB-500 (Ac-LKKTETQ) — 7-residue thymosin beta-4 fragment. Wholesale research supply, COA/HPLC-MS, private-label bulk available.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- N-acetylated form (Ac-LKKTETQ-OH) per analytical standard
- Available in research vial sizes and bulk aliquot programs
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping and storage documentation available
- Private-label and white-label bulk inquiry available
- TFA-free salt form available on request
Scientific Identifiers
| Sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln-OH (LKKTETQ) |
|---|---|
| Residue count | 7 |
| Molecular formula | C38H68N10O14 |
| Molecular weight | ~848.99 g/mol |
| PubChem CID | 62707662 |
| Note | Full thymosin beta-4 (43 residues, C212H350N56O78S) is distinct from TB-500 which is the fragment only |
Research Mechanism Summary
TB-500 corresponds to the N-acetylated heptapeptide fragment (residues 17–23) of thymosin beta-4, a 43-residue endogenous signaling protein first isolated from thymus tissue; its primary documented mechanism is high-affinity (Kd ~0.5–0.7 μM) binding to monomeric G-actin, sequestering it to prevent F-actin polymerization and enabling rapid cytoskeletal remodeling critical for cell migration (https://www.peptideknow.com/peptides/tb-500). Preclinical studies demonstrate that this fragment also upregulates VEGF mRNA expression (2.5–3.8-fold) and modulates NF-κB signaling, reducing pro-inflammatory cytokine levels (TNF-α, IL-1β, IL-6) by 40–60% in injury models (https://pubmed.ncbi.nlm.nih.gov/23050815/). Research models include wound healing, cardiac ischemia-reperfusion, and corneal epithelial repair; no completed human clinical trials for the synthetic fragment are on record.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
TB-500 is supplied as a research-grade lyophilized peptide catalog item under the Recovery & Repair Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies TB-500 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.