GHK-Cu — Research Peptide Bulk Supply

• Lyophilized powder, ≥98% purity by HPLC-MS (copper chelation confirmed)
• Molecular weight: 744.3 g/mol (as copper complex)
• Available in research quantities (50 mg to 1000 mg) and bulk programs
• COA with HPLC and elemental analysis (copper content) per lot
• Also available as GHK basic (copper-free tripeptide) — see catalog variant
• Cold-chain shipping and storage documentation
• Private-label and white-label bulk inquiry available

GHK-Cu is the copper(II) complex of the tripeptide Gly-His-Lys, an endogenous human plasma peptide that declines with age; in fibroblast culture models it stimulates collagen, elastin, and glycosaminoglycan synthesis at picomolar to nanomolar concentrations (10⁻¹² to 10⁻⁹ M), and modulates metalloproteinase (MMP-1, MMP-2, MMP-9) activity and their inhibitors (TIMP-1, TIMP-2), functioning as a general regulator of extracellular matrix remodeling (https://pubmed.ncbi.nlm.nih.gov/3169264/). Mechanistic research establishes that GHK activates TGF-β and integrin β1 pathways during tissue repair, attracts immune and endothelial cells to wound sites, and restores gene expression patterns toward a healthier fibroblast phenotype in models of aging and radiation damage (https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/). A 2018 review in IJMS characterizes its role in collagen production, nerve outgrowth stimulation, and dermal stem cell marker expression (https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/).

For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.

• https://pubchem.ncbi.nlm.nih.gov/compound/133697840
• https://pubmed.ncbi.nlm.nih.gov/3169264/
• https://pmc.ncbi.nlm.nih.gov/articles/PMC4508379/
• https://pmc.ncbi.nlm.nih.gov/articles/PMC6073405/