KPV — Research Peptide Bulk Supply
Also known as: MSH(11-13), Lys-Pro-Val, α-MSH C-terminal tripeptide, alpha-melanocyte stimulating hormone 11-13
KPV (Lys-Pro-Val) — α-MSH C-terminal anti-inflammatory tripeptide. Wholesale bulk supply, COA/HPLC-MS, private-label inquiry.
Bulk Catalog Specifications
- Lyophilized powder, ≥98% purity by HPLC-MS
- Molecular weight: 342.43 g/mol (tripeptide)
- Available in research vial sizes (5 mg) and bulk aliquot programs
- COA with HPLC and mass spectrometry data per lot
- Cold-chain shipping and storage documentation
- Private-label and white-label bulk inquiry available
Scientific Identifiers
| Sequence | Lys-Pro-Val (KPV) |
|---|---|
| Residue count | 3 |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.43 g/mol |
| PubChem CID | 125672 |
| Note | CID 125672 corresponds to MSH(11-13)/Lys-Pro-Val |
Research Mechanism Summary
KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH); research demonstrates it retains the anti-inflammatory activity of the full 13-residue peptide without pigmentation effects, modulating inflammation through NF-κB translocation inhibition rather than through classical MC1R/cAMP pathways (https://pubmed.ncbi.nlm.nih.gov/12750433/). Studies in peritonitis and colitis models show KPV reduces neutrophil accumulation, inhibits macrophage IL-1β release, and blocks surface binding of IL-1β to T-cell receptors, suggesting a direct IL-1 antagonist mechanism independent of melanocortin receptors (https://pmc.ncbi.nlm.nih.gov/articles/PMC2095288/). Its preserved anti-inflammatory profile and low molecular weight position it as an extensively studied research tool for inflammatory bowel, skin, and joint inflammation models (https://pubmed.ncbi.nlm.nih.gov/18612139/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
KPV is supplied as a research-grade lyophilized peptide catalog item under the Immune & Antimicrobial Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies KPV in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.