Tuftsin — Research Peptide Bulk Supply
Also known as: TKPR, Thr-Lys-Pro-Arg, threonyl-lysyl-prolyl-arginine
Tuftsin (TKPR) is a naturally occurring tetrapeptide from IgG studied for macrophage phagocytosis activation and immunostimulation. Bulk research specs.
Bulk Catalog Specifications
- Lyophilized powder
- Purity ≥98% (HPLC)
- Residue count: 4 (tetrapeptide)
- Supplied as TFA or acetate salt
- Storage: −20°C, desiccated
- COA topics: HPLC, MS, peptide content by nitrogen
Scientific Identifiers
| Sequence | H-Thr-Lys-Pro-Arg-OH (TKPR) |
|---|---|
| Residue count | 4 |
| Molecular formula | C21H40N8O6 |
| Molecular weight | 500.6 g/mol |
| PubChem CID | 156080 |
Research Mechanism Summary
Tuftsin (Thr-Lys-Pro-Arg) is a tetrapeptide cleaved from the CH2 domain of immunoglobulin G heavy chain that binds neuropilin-1 (Nrp-1) receptors on macrophages, monocytes, and neutrophils, promoting phagocytic burst activity and antigen processing. In vitro studies show tuftsin enhances macrophage production of TNF-α and reactive intermediates, while animal models demonstrate augmented antitumor cytotoxicity and antigen-dependent cell-mediated immunity. The native peptide has a plasma half-life of approximately 2.8 hours due to carboxypeptidase susceptibility, driving interest in structurally stabilized analogs for research use.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Tuftsin is supplied as a research-grade lyophilized peptide catalog item under the Immune & Antimicrobial Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Tuftsin in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.