Thymulin — Research Peptide Bulk Supply

• Lyophilized powder
• Purity ≥95% (HPLC)
• Residue count: 9 amino acids
• Zinc-dependent bioactivity (supplied as apo-peptide)
• Storage: −20°C, desiccated
• Reconstitution: sterile water or 0.1% acetic acid
• COA topics: HPLC purity, MS confirmation, residual solvents

Thymulin (H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH) is a nonapeptide secreted by thymic epithelial cells that requires 1:1 zinc coordination for biological activity; zinc binding induces a three-dimensional conformation required for receptor engagement on T-lymphocytes. Preclinical studies demonstrate thymulin influences intrathymic and extrathymic T-cell differentiation, promoting Th1 cytokine balance (IFN-γ upregulation, IL-13 reduction) in murine asthma models. Signaling investigations indicate thymulin suppresses NF-κB nuclear translocation and p38 MAPK activation, with bidirectional neuroendocrine interactions including stimulation by growth hormone and prolactin at thymic epithelial GH/PRL receptors.

For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.

• https://pubchem.ncbi.nlm.nih.gov/compound/71300623
• https://en.wikipedia.org/wiki/Thymulin
• https://pubmed.ncbi.nlm.nih.gov/6609827/
• https://www.sciencedirect.com/science/article/abs/pii/S0161589009007482
• https://pmc.ncbi.nlm.nih.gov/articles/PMC1905732/
• https://www.selleckchem.com/peptide/thymulin.html