Thymosin Beta-4 (Full Length) — Research Peptide Bulk Supply
Also known as: TB-4, Tβ4, TMSB4X protein peptide, Thymosin β4
Thymosin Beta-4 (TB-4) is a 43-aa actin-sequestering peptide studied for tissue repair, angiogenesis, and anti-inflammatory signaling. Full-length research specs.
Bulk Catalog Specifications
- Recombinant or synthetic full 43-aa sequence
- Lyophilized powder
- Purity ≥95% (HPLC-MS confirmed)
- MW ~4963 Da
- Storage: −80°C long-term, −20°C short-term
- COA topics: HPLC, MS/MS sequence confirmation, bioactivity lot data
Scientific Identifiers
| Sequence | Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES-NH2 (human) |
|---|---|
| Residue count | 43 |
| Molecular formula | C212H350N56O78S |
| Molecular weight | 4963.4 g/mol |
| PubChem CID | 16129610 (Thymosin beta-4) |
Research Mechanism Summary
Thymosin Beta-4 is a 43-amino-acid intracellular actin-sequestering peptide that binds monomeric G-actin, preventing premature polymerization and enabling controlled cell migration during tissue repair. Beyond actin regulation, TB-4 has been shown to upregulate vascular endothelial growth factor (VEGF) and promote endothelial tube formation in angiogenesis research, while inhibiting TNF-α-driven NF-κB activation and reducing IL-1β pro-inflammatory output. TB-4 has undergone clinical trials for dry eye syndrome (ReST study) and acute myocardial infarction (Pilot-in-AMI), documenting a human pharmacokinetic and safety profile distinct from its fragment analog TB-500.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Thymosin Beta-4 (Full Length) is supplied as a research-grade lyophilized peptide catalog item under the Immune & Antimicrobial Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Citations & Sources
- https://pubchem.ncbi.nlm.nih.gov/compound/16129610
- https://bc9.co/thymosin-beta-4-vs-tb-500-related-peptides-distinct-compounds/
- https://oathresearch.com/2025/11/09/tb-500-vs-thymosin-beta-4-whats-different/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9974367/
- https://purehealthpeptides.com/tb-500-vs-thymosin-beta-4-understanding-the-key-differences/
Wholesale & Documentation
PeptideDistro.com supplies Thymosin Beta-4 (Full Length) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.