Thymagen (Glu-Trp) — Research Peptide Bulk Supply

• Lyophilized powder
• Purity: >99% by HPLC
• Available research vial sizes: 10 mg, 20 mg
• Storage: -20°C, protect from light
• Solubility: Soluble in water
• COA with HPLC and mass spectrometry data provided per lot
• Cold-chain shipping documentation available
• Private-label and white-label bulk inquiry form available

Thymagen (L-Glu-L-Trp) is a synthetic dipeptide bioregulator extracted and characterized from thymalin, where it was identified as the EW component responsible for T-cell immune modulation. At the molecular level, Khavinson et al. identified selective binding of the EW motif to the AACG nucleotide sequence in DNA, suggesting epigenetic regulation of gene expression patterns in immune cells. Functionally, Thymagen modulates the intracellular cAMP/cGMP ratio by influencing phosphodiesterase activity, normalizing cyclic nucleotide balance critical for immune cell activation (https://www.corepeptides.com/thymagen-peptide-research-into-immune-cell-regulation-and-activation/). A 12-month rodent study showed that the dipeptide reduced maximum-lifespan aging rate (Gompertz α) from 0.0071 to 0.0041 day⁻¹ and decreased total tumor incidence by approximately 1.5-fold and hematopoietic malignancies by 3.4-fold, providing a longevity-research context (https://pubmed.ncbi.nlm.nih.gov/11707921/). Secondary studies examine protective effects against Yersinia infection and polyclonal immune activation.

For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.

• https://pubmed.ncbi.nlm.nih.gov/11707921/
• https://pmc.ncbi.nlm.nih.gov/articles/PMC8365293/
• https://www.corepeptides.com/thymagen-peptide-research-into-immune-cell-regulation-and-activation/