Nonapeptide-1 — Research Peptide Bulk Supply
Also known as: MC1R antagonist peptide, Melanin inhibiting nonapeptide, Melanostatine-5
Nonapeptide-1 is a 9-AA MC1R competitive antagonist studied for melanogenesis inhibition and hyperpigmentation research. Lyophilized, >99% purity.
Cosmetic peptides are listed for catalog supply and bulk research framing only. PeptideDistro.com makes no cosmetic-product, anti-aging, dermatological, hair-growth, treatment, or consumer-use claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 50 mg, 100 mg, 200 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | 9-AA α-MSH antagonist sequence (exact sequence per manufacturer COA) |
|---|---|
| Residue count | 9 |
| Molecular formula | TBD |
| Molecular weight | TBD |
Research Mechanism Summary
Nonapeptide-1 is a 9-amino-acid biomimetic peptide that functions as a competitive antagonist of the melanocortin-1 receptor (MC1R) on melanocytes. It competes with α-MSH for binding to MC1R with a Ki of approximately 40 nM and an IC50 of approximately 11 nM, preventing cAMP elevation and downstream tyrosinase activation—the enzymatic gateway to melanogenesis. In melanocyte models, Nonapeptide-1 reduces α-MSH-induced cAMP levels and melanosome dispersion, inhibiting melanin synthesis by approximately 33% (https://www.activepeptide.com/product/nonapeptide-1/). Unlike cytotoxic depigmenting agents, it operates through receptor competitive blockade without injuring melanocytes. Research also attributes secondary actions to mitochondrial energy support and circadian rhythm regulation in skin cells. Nonapeptide-1 is positioned in hyperpigmentation, melasma, and MC1R-signaling research alongside Decapeptide-12 (tyrosinase inhibitor) and Melanotan-1 (agonist).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Nonapeptide-1 is supplied as a research-grade lyophilized peptide catalog item under the Skin & Hair Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Nonapeptide-1 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.