Melanotan-1 (Afamelanotide) — Research Peptide Bulk Supply
Also known as: MT-1, Afamelanotide, NDP-alpha-MSH, 4-Nle-7-D-Phe-alpha-MSH, Scenesse (pharmaceutical form)
Melanotan-1 (afamelanotide) is a 13-AA α-MSH analogue studied for MC1R-mediated melanogenesis. PubChem CID 16154396, >99% purity, lyophilized.
Afamelanotide (Scenesse) is the FDA-approved formulation of this 13-residue α-MSH analogue, indicated for erythropoietic protoporphyria. The page below frames mechanism literature (melanocortin receptor pharmacology, photoprotection research) only and makes no consumer or treatment claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 5 mg, 10 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in sterile water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val (13 AA) |
|---|---|
| Residue count | 13 |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.87 g/mol |
| PubChem CID | 16154396 |
Research Mechanism Summary
Melanotan-1 (afamelanotide) is a 13-amino-acid synthetic analogue of α-MSH incorporating two stabilizing substitutions: norleucine at position 4 and D-phenylalanine at position 7. These modifications confer approximately 1,000-fold greater potency at the melanocortin-1 receptor (MC1R) versus native α-MSH and extend its plasma half-life. MC1R activation initiates cAMP-dependent signaling in melanocytes, upregulating microphthalmia-associated transcription factor (MITF) and downstream eumelanin biosynthesis enzymes including tyrosinase—producing UV-protective melanin without requiring UV exposure in vitro (https://biolongevitylabs.com/product/melanotan-1-10mg/). In three Phase II/III clinical trials in erythropoietic protoporphyria (EPP) patients, afamelanotide-treated subjects tolerated approximately 64 hours of sunlight exposure vs. approximately 40 hours in placebo groups. Anti-inflammatory and antifibrotic effects through downregulation of TGF-β1, COX-2, and α-SMA are also under active preclinical investigation in liver fibrosis models (https://www.corepeptides.com/peptides/melanotan-1-10mg/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Melanotan-1 (Afamelanotide) is supplied as a research-grade lyophilized peptide catalog item under the Melanocortin Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Melanotan-1 (Afamelanotide) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.