Decapeptide-12 — Research Peptide Bulk Supply
Also known as: Tyrosinase-inhibiting decapeptide, Melanogenesis inhibitor peptide, Laightest
Decapeptide-12 is a 10-AA tyrosinase-inhibiting peptide studied for melanogenesis and sirtuin pathway research. Lyophilized, >99% purity.
Cosmetic peptides are listed for catalog supply and bulk research framing only. PeptideDistro.com makes no cosmetic-product, anti-aging, dermatological, hair-growth, treatment, or consumer-use claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 50 mg, 100 mg, 200 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | 10-AA; includes Tyr-Ser-Ser-Trp-Tyr core; full sequence in Abu Ubeid et al. |
|---|---|
| Residue count | 10 |
| Molecular formula | TBD |
| Molecular weight | TBD |
Research Mechanism Summary
Decapeptide-12 is a 10-amino-acid peptide (sequence includes Tyr-Ser-Ser-Trp-Tyr motif) developed by dermatological researchers at Stanford University to competitively inhibit tyrosinase, the rate-limiting enzyme in melanogenesis. Unlike cytotoxic bleaching agents, Decapeptide-12 binds reversibly within the tyrosinase active pocket, preferentially blocking the monophenolase (tyrosine-hydroxylase) reaction over the diphenolase reaction—the gatekeeping step for melanin biosynthesis. Abu Ubeid et al. demonstrated ~35% tyrosinase activity inhibition in melanocyte lysates and >40% reduction in intracellular melanin content after 7 days in cultured melanocytes without measurable cytotoxicity (https://www.corepeptides.com/decapeptide-12-studies-in-skin-cell-lightening-and-anti-aging/). An animal model of melasma (photodamage) showed grade-level improvement in approximately 40% of subjects. Additionally, Decapeptide-12 upregulates SIRT1, SIRT3, and SIRT6 by 120–150% over baseline in keratinocytes, suggesting a secondary anti-aging/sirtuin-pathway research application.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Decapeptide-12 is supplied as a research-grade lyophilized peptide catalog item under the Skin & Hair Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Decapeptide-12 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.