Matrixyl (Palmitoyl Pentapeptide-4) — Research Peptide Bulk Supply

• Lyophilized powder
• Purity: >99% by HPLC
• Available research vial sizes: 50 mg, 100 mg, 200 mg
• Storage: -20°C, protect from light
• Solubility: Soluble in water with slight warming; DMSO for concentrated stock
• COA with HPLC and mass spectrometry data provided per lot
• Cold-chain shipping documentation available
• Private-label and white-label bulk inquiry form available

Matrixyl (palmitoyl pentapeptide-4) is a lipid-conjugated pentapeptide (Pal-Lys-Thr-Thr-Lys-Ser) that mimics the collagen matrikine KTTKS, a breakdown product of collagen type I that signals dermal fibroblasts to synthesize new extracellular matrix proteins. The palmitoyl chain enhances stratum corneum penetration. In fibroblast cultures, Matrixyl upregulates collagen types I, III, and IV, fibronectin, and glycosaminoglycans including hyaluronic acid through receptor-mediated signaling similar to endogenous matrikine feedback (https://biotechpeptides.com/2024/10/08/matrixyl-peptide-potential-impacts-on-cellular-aging-and-wound-repair/). A randomized, split-face clinical trial in 93 women aged 35–55 showed significant periorbital wrinkle depth reduction vs. placebo over 12 weeks; a second 8-week periorbital study outperformed both placebo and comparator peptides (Robinson et al., Int J Cosmet Sci, 2005; https://pubmed.ncbi.nlm.nih.gov/18492182/). Secondary studies investigate inhibition of myofibroblast transdifferentiation through α-SMA modulation, relevant to scar-quality models.

For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.

• https://pubmed.ncbi.nlm.nih.gov/18492182/
• https://biotechpeptides.com/2024/10/08/matrixyl-peptide-potential-impacts-on-cellular-aging-and-wound-repair/
• https://www.corepeptides.com/peptides/matrixyl-200mg/