Acetyl Hexapeptide-3 (Argireline) — Research Peptide Bulk Supply
Also known as: Acetyl Hexapeptide-8, Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, Argireline acetate
Argireline (acetyl hexapeptide-3) is a SNAP-25 fragment peptide studied for neuromuscular signaling and skin research. >99% purity, lyophilized.
Cosmetic peptides are listed for catalog supply and bulk research framing only. PeptideDistro.com makes no cosmetic-product, anti-aging, dermatological, hair-growth, treatment, or consumer-use claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 50 mg, 100 mg, 200 mg
- Storage: -20°C, protect from moisture
- Solubility: Soluble in water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 |
|---|---|
| Residue count | 6 |
| Molecular formula | C34H60N14O12S (as free peptide, may vary by salt form) |
| Molecular weight | 888.99 g/mol |
| PubChem CID | 71587772 |
Research Mechanism Summary
Argireline (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2) is a synthetic hexapeptide fragment of SNAP-25, a component of the SNARE complex that mediates synaptic vesicle exocytosis and acetylcholine release at neuromuscular junctions. By competitively inhibiting SNARE complex formation, the peptide is studied for its capacity to reduce neurotransmitter-driven muscle contraction in vitro and in topical models. A double-blind clinical study found that a 5% acetyl hexapeptide-3 semi-solid formulation applied twice daily for 30 days reduced periorbital rhytid depth by ~27% (Dana & Rotsztejn, 2017; https://pmc.ncbi.nlm.nih.gov/articles/PMC5785486/). Secondary research areas include transepidermal water loss reduction and synergy with neurotoxin analogue studies for extended myorelaxant profiles. The palmitoylated form (palmitoyl hexapeptide-3) is additionally investigated for antinociceptive effects via TRPV1 channel modulation in inflammatory pain models.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
Acetyl Hexapeptide-3 (Argireline) is supplied as a research-grade lyophilized peptide catalog item under the Skin & Hair Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies Acetyl Hexapeptide-3 (Argireline) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.