B7-33 — Research Peptide Bulk Supply
Also known as: B7-33 relaxin analogue, Relaxin B-chain analogue, RXFP1 biased agonist
B7-33 is a synthetic single-chain RXFP1 biased agonist derived from human relaxin-2. Research peptide, lyophilized, >99% purity. For lab use only.
B7-33 is a single-chain B-chain-only analogue of human relaxin-2, listed for cardiovascular and fibrosis research framing only. Preclinical literature only — no human clinical or treatment claims are made.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 2 mg, 5 mg, 6 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in water or aqueous buffer
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | Single-chain B-chain-only analogue of H2 relaxin; exact sequence per RSC publication 2016 |
|---|---|
| Residue count | 33 |
| Molecular formula | TBD |
| Molecular weight | TBD |
Research Mechanism Summary
B7-33 is a synthetic single-chain analogue of the B-chain of human relaxin-2 (H2 relaxin), designed to bind the relaxin family peptide receptor 1 (RXFP1) with functional selectivity. Unlike full relaxin-2, B7-33 preferentially activates the pERK1/2 signaling pathway over the canonical cAMP pathway in cells endogenously expressing RXFP1, an approach termed 'biased agonism' (https://pubs.rsc.org/en/content/articlelanding/2016/sc/c5sc04754d). In a murine myocardial infarction model, B7-33 significantly reduced infarct size (22% vs 45% in vehicle), preserved fractional shortening at 7 days post-MI, and attenuated endoplasmic reticulum stress markers including GRP78 in primary cardiomyocytes (https://pmc.ncbi.nlm.nih.gov/articles/PMC7428518/). Preclinical studies also indicate vasoprotective and antifibrotic properties consistent with relaxin-2 pharmacology, with lower synthesis costs owing to the absence of the disulfide A-chain.
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
B7-33 is supplied as a research-grade lyophilized peptide catalog item under the Cardiovascular & Fibrosis Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies B7-33 in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.