PTD-DBM — Research Peptide Bulk Supply
Also known as: Protein Transduction Domain-Dvl Binding Motif, CXXC5-Dvl inhibitor peptide
PTD-DBM is a synthetic Wnt/β-catenin pathway peptide studied for hair follicle and wound healing research. Lyophilized, >99% purity. Research use only.
Cosmetic peptides are listed for catalog supply and bulk research framing only. PeptideDistro.com makes no cosmetic-product, anti-aging, dermatological, hair-growth, treatment, or consumer-use claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 2 mg, 5 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in sterile water or DMSO
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | PTD + DBM fusion; exact sequence from Lim et al. Sci Transl Med 2018 |
|---|---|
| Molecular formula | C124H224N61O28S2 (approximate per catalog listing) |
| Molecular weight | ~3000+ g/mol |
Research Mechanism Summary
PTD-DBM is a fusion peptide consisting of a protein transduction domain (PTD) for membrane penetration and a Dishevelled (Dvl) binding motif (DBM) for intracellular targeting. Once internalized, DBM competitively blocks the interaction between CXXC5—a negative feedback regulator of Wnt signaling—and Dvl, thereby disinhibiting the Wnt/β-catenin pathway. In murine androgenetic alopecia models, PTD-DBM promoted new hair follicle formation and stimulated the anagen phase through upregulation of β-catenin, alkaline phosphatase, and PCNA (https://biotechpeptides.com/product/ptd-dbm-5mg/). Co-administration with valproic acid (a GSK3β inhibitor) produced synergistic hair regrowth and new follicle neogenesis in vivo. PTD-DBM also accelerated cutaneous wound closure in mice by activating fibroblast-to-myofibroblast differentiation and collagen I synthesis through β-catenin stabilization (https://www.novoprolabs.com/p/ptd-dbm-318831.html).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
PTD-DBM is supplied as a research-grade lyophilized peptide catalog item under the Skin & Hair Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies PTD-DBM in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.