CJC-1295 DAC (DAC:GRF) — Research Peptide Bulk Supply
Also known as: DAC:GRF, Drug Affinity Complex GHRH, CJC-1295 with DAC, Long-acting GHRH analogue
CJC-1295 DAC (DAC:GRF) is an albumin-binding GHRH analogue with extended half-life, studied for sustained GH axis signaling research. >99% purity.
CJC-1295 DAC carries a maleimidopropionyl (Drug Affinity Complex) linker that reversibly binds serum albumin to extend the GHRH analogue half-life. Listed for GH axis pharmacology research only; PeptideDistro.com makes no clinical, performance, or treatment claims.
Bulk Catalog Specifications
- Lyophilized powder
- Purity: >99% by HPLC
- Available research vial sizes: 2 mg, 5 mg
- Storage: -20°C, protect from light
- Solubility: Soluble in sterile water
- COA with HPLC and mass spectrometry data provided per lot
- Cold-chain shipping documentation available
- Private-label and white-label bulk inquiry form available
Scientific Identifiers
| Sequence | Modified GHRH 1-29 + DAC albumin-binding modification (see ConjuChem patent) |
|---|---|
| Residue count | 30 |
| Molecular formula | TBD |
| Molecular weight | ~3647 g/mol (backbone; varies with DAC salt form) |
Research Mechanism Summary
CJC-1295 DAC (DAC:GRF) is a 29-amino-acid GHRH analogue sharing the CJC-1295 peptide backbone but conjugated with a Drug Affinity Complex (DAC) that reversibly binds serum albumin, dramatically extending its plasma half-life from approximately 30 minutes (for CJC-1295 no-DAC) to 6–8 days. This extended half-life is achieved through reduced renal clearance and protection from dipeptidyl peptidase-4 (DPP-4) enzymatic degradation. In pituitary cell research models, DAC:GRF activates GHRH receptors to stimulate GH synthesis and secretion through cAMP/PKA signaling. The sustained albumin-binding pharmacokinetics make CJC-1295 DAC valuable for studying prolonged GHRH receptor activation versus pulsatile stimulation, including downstream effects on IGF-1 levels and metabolic signaling in fat, muscle, and bone cell models (https://en.wikipedia.org/wiki/CJC-1295; https://simplepeptide.com/product/cjc-1295-w-dac-5mg/).
For Research Use Only. Not for human or veterinary use. Page copy reflects published preclinical and biochemistry literature only and does not constitute dosage, administration, treatment, or therapeutic guidance.
Catalog Context
CJC-1295 DAC (DAC:GRF) is supplied as a research-grade lyophilized peptide catalog item under the GH Secretagogue Research Peptides family. PeptideDistro.com lists this entry for qualified research and wholesale buyers; pricing, MOQ, and documentation packets are reviewed during account intake. Page copy is framed exclusively around mechanism literature, molecular identifiers, and bulk catalog specifications.
Wholesale & Documentation
PeptideDistro.com supplies CJC-1295 DAC (DAC:GRF) in research-grade lyophilized format with COA, HPLC, and mass spectrometry data per lot. Pricing, MOQ, and label coordination are reviewed during account intake.